Blood SubstitutesBlood substitutes are solutions designed for use in patients who need blood transfusions, but for whom whole blood is not available, or is not safe. This interest has intensified in the wake of the AIDS and hepatitis C epidemics. Blood Substitutes describes the rationale, current approaches, clinical efficacy, and design issues for all blood substitutes now in clinical trials. The many summary diagrams and tables help make the book accessible to readers such as surgeons and blood bankers, who have less technical expertise than the biochemists and hematologists who are designing and testing blood substitutes. * Includes chapters necessary to the understanding of blood substitutes, including history, toxicity, physiology, and clinical applications* Presents detailed descriptions of the various products that have been developed and have advanced to clinical trials, and some that are in earlier states of development |
Contents
1 | |
3 | |
43 | |
Clinical Applications | 113 |
Toxicity and Side Effects | 195 |
PerfluorocarbonBased Oxygen Carriers | 257 |
HemoglobinBased Oxygen Carriers | 325 |
Liposomes and Related Products | 499 |
541 | |
549 | |
Other editions - View all
Blood Substitutes: New Challenges Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta Limited preview - 2012 |
Blood Substitutes: New Challenges Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta Limited preview - 1996 |
Blood Substitutes: New Challenges Robert M. Winslow,Kim D. Vandegriff,Marcos Intaglietta No preview available - 2011 |
Common terms and phrases
acute Alayash allogeneic anemia animals arterial Artif Biol blood flow blood substitute blood transfusion bovine hemoglobin capillary cardiac output cell substitutes cell-free hemoglobin Cells Blood Subst cent Chem circulation clinical trials colloid coronary crosslinked hemoglobin DCLHb decreased dextran diaspirin diffusion dose effects efficacy emulsion exchange transfusion Figure fluid Fluosol function g/dl globin HBOCs hematocrit heme hemo hemodilution hemoglo hemoglobin hemoglobin solutions Hemopure hemorrhagic shock human hemoglobin Immob increased infusion Intaglietta ischemia lesions lipid membrane metabolism methemoglobin microcirculation mmHg molecular molecules myocardial myoglobin nitric oxide oxygen affinity oxygen delivery oxygen transport Oxygent patients PEGylation perflubron perfluorocarbon Perftoran perfusion Physiol physiological plasma plasma viscosity PolyHeme polymerized polymers pressure protein rats reaction recombinant red blood cells red cell redox reduced renal resuscitation Ringer’s saline stability studies subunits surgery tion tissue oxygenation toxicity trauma Vandegriff vascular vasoconstriction viscosity vivo volume Winslow
Popular passages
Page 34 - Administration with respect to such drug, there is lack of substantial evidence consisting of adequate and well-controlled investigations, including clinical investigations, by experts qualified by scientific training and experience to evaluate the effectiveness of the drug involved, on the basis of which it could fairly and responsibly be concluded by such experts that the drug will have the effect it purports or is represented to have under the conditions of use prescribed, recommended, or suggested...
Page 32 - Hebert PC, Wells G, Blajchman MA, et al. A multicenter randomized, controlled clinical trial of transfusion requirements in critical care.
Page 35 - potency" is interpreted to mean the specific ability or capacity of the product, as indicated by appropriate laboratory tests or by adequately controlled clinical data obtained through the administration of the product in the manner intended, to effect a given result. (u) "Manufacturer" means any legal person or entity engaged in the manufacture of a product subject to license under the act.
Page 6 - I was pleased to see the person who had his blood taken out. He speaks well, and did this day give the Society a relation thereof in Latin, saying that he finds himself much better since, and as a new man, but he is cracked a little in his head, though he speaks very reasonably, and very well.
Page 37 - Subjects are facing a life-threatening situation that necessitates intervention; (ii) Appropriate animal and other preclinical studies have been conducted, and the information derived from those studies and related evidence support the potential for the intervention to provide a direct benefit to the individual subjects...