Polio Vaccines: Hearings Before a Subcommittee of the Committee on Interstate and Foreign Commerce, Eighty-seventh Congress, First Session, March 16 and 17, 1961Includes AMA, "Symposium on Present Status of Poliomyelitis and Poliomyelitis Immunization: Papers Presented at AMA Mid-Winter Clinical Session," Nov. 30, 1960 (p. 12-104), and paper by Dr. Albert B. Sabin, Dr. Richard H. Michaels, Dr. Ilya Spigland, William Pelon, Dr. Johng S. Rhim, and Dr. R. Eugene Wehr, "Effectiveness of Community-Wide Vaccination with Oral Attenuated Poliovirus Vaccine in Cincinnati" (p. 189-245) |
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administration age group agents Albert Sabin American Medical Association antibody antigen areas attenuated poliovirus Biologics Standards Burney cells Chairman Cincinnati clinics Committee on Live Committee on Poliomyelitis Communicable Disease Center community-wide CONGRESS THE LIBRARY Division of Biologics effective epidemic field trials Hamilton County health department Health Organization immunization indicated infection inoculated killed vaccine KURLANDER laboratory LANGMUIR Lederle licensing live polio live poliovirus vaccine live vaccine live virus vaccine manufacture million monovalent months MURRAY National Foundation neurovirulence oral polio vaccine oral vaccine paralytic polio paralytic poliomyelitis percent Pfizer physicians Poliomyelitis Control poliomyelitis vaccine population potency pre-school children present problem production Public Health Service question recommended requirements ROBERTS ROGERS of Florida Sabin strains Sabin vaccine safety Salk vaccine simian studies subcommittee Surgeon surveillance TERRY tests tion tissue culture U.S. Public Health United unvaccinated vaccine program viremia World Health Organization
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Page 139 - The Surgeon General shall conduct in the Service, and encourage, cooperate with, and render assistance to other appropriate public authorities, scientific institutions, and scientists in the conduct of, and promote the coordination of, research, investigations, experiments, demonstrations, and studies relating to the causes, diagnosis, treatment, control, and prevention of physical and mental diseases and impairments of man, including water purification, sewage treatment, and pollution of lakes and...
Page 349 - ... 5.0 ml. of the monovalent virus pool to be tested. The animals shall be observed for at least 42 days and daily rectal temperatures recorded for the last 3 weeks of the test. Each animal that dies after the first 24 hours of the test, or is sacrificed because of illness, shall be necropsied...
Page 172 - I will answer any questions you may have to the best of my ability. Senator GLENN. Thank you very much. Sergeant Major McKinney. STATEMENT OF SGT. MAJ. CA "MACK" McKINNEY, US MARINE CORPS (RETIRED), LEGISLATIVE COUNCIL, NON-COMMISSIONED OFFICERS ASSOCIATION Sergeant McKiNNEY.
Page 349 - ... additional mice which shall be observed for 21 days. The monovalent virus pool may be used for poliovirus vaccine only if at least 80 percent of the mice remain healthy and survive the entire period and if all the mice used in the test fail to show evidence of lymphocytic choriomeningitis virus or other viral infection. (3) Inoculation of suckling mice. Each of at least 20 suckling mice less than 24 hours old, shall be inoculated intracerebrally with 0.01 ml. and intraperitoneally with 0.1 ml....
Page 350 - The animals shall be examined to ascertain whether the distribution and histological nature of the lesions are characteristic of poliovirus infection. A comparative evaluation shall be made of the evidence of neurovirulence of the virus under test and the...
Page 350 - The neurovirulence tests are not valid unless the sample contains at least 107 ° TCIDo0 per ml. when titrated in comparison with the Reference Poliovirus, Live, Attenuated of the appropriate type. All monkeys shall be observed for 17 to 21 days, under the supervision of a qualified pathologist, physician or veterinarian, and any evidence of physical abnormalities indicative of poliomyelitis or other viral infections shall be recorded. (i) Intrathalamic inoculation. Each of at least 30 monkeys shall...
Page 148 - That from and after six months after the promulgation of the regulations authorized by section four of this act no person shall sell, barter, or exchange, or offer for sale, barter, or exchange in the District of Columbia, or send, carry, or bring for sale, barter, or exchange from any State...
Page 226 - R. : Use of Sabin's Live Poliovirus Vaccine in Mexico. Results of a LargeScale Trial, ibid., pp.
Page 340 - Summary. 336. MELNICK, JOSEPH L. (Baylor Univer. Coll. Med., Houston, Texas), BENYESH-MELNICK, MATILDA, & BRENNAN, JAMES C. Studies on live polio-virus vaccine: Its neurotropic activity in monkeys and its increased neurovirulence after multiplication in vaccinated children. J. Amer. med. Ass., 1959, 171, 1 165-1172.
Page 352 - Modification of any particular manufacturing method or process or the conditions under which it is conducted as set forth in the additional standards relating to Poliovirus Vaccine, Live, Oral, shall be permitted whenever the manufacturer presents evidence that demonstrates...