SOME CONTRIBUTIONS TO DRUG ERUPTIONS IN 1895. ANTIPYRINE.-Dr. F. H. Pritchard gives in abstract from Ann. de Dermatologie an account of four cases of localized persistent erythema from antipyrine observed by L. Brocq of Paris. The eruption appeared in a few isolated patches here and there on the skin without symmetry; some were of large size. They were reddish-gray at first, then disappeared slowly leaving a brownish pigmentation; after repeated outbreaks always in the same spot, the staining sometimes became a blackish-brown. Occasionally vesicles formed, or swelling of the skin occurred, and almost always there was lamellar desquamation with a fading of the redness. The patches were clearly defined and pigmentation disappeared from the smaller if the drug was discontinued in two or three weeks. When the drug was continued new eruptions of erythema occurred on the old sites with consecutive increase of pigmentation. The duration of the eruption was in some cases from one to six months.--Jour. Cut. Gen-Urin. Dis., March, 1895.

A PUBLISHED CASE OF ANTIPYRINE EXANTHEMATA similating the roseola of syphilis has been translated from the same journal by Dr. Pritchard. This case came to the St. Louis Hospital where Fournier and all who saw it declared it was a syphilitic roseola, but the patient denied such a possibility and no other evidences of syphilis could be found. It was learned that the outbreak had appeared after he had taken thirty grains a day of antipyrine, two days in succession. Fournier related a case of an eruption from the same drug, which exhibited nearly all the symptoms of measles, such as fever, lachrymation, coryza and lesions, but did not develop a bronchitis.-Ibid, May, 1895.

ARSENIC.-Dr. Colcott Fox has reported (British Journal Dermatol., Jan., 1895), the case of a woman of 26, who, after taking liquor arsenicalis in five, increased to eight minim doses three times a day in an iron and quinine mixture for about seven weeks, for lichen planus had appeared at this time, and while the lichen lesions were fast disappearing, an eruption pemphigus bullæ of all sizes up to a pigeon's egg on the chin, forearms and nose. These arose directly from the sound skin as well as from the site of the lichen lesions. During the further continuance of the arsenic mixture for three weeks, the bullæ continued to evolve in great numbers and some appeared in the mouth. The patient had experienced repeated ague-like chills, aching in the arms and wrists and felt generally sick.

Dr. Juliano Moreira in a clinical paper on Arsenical Affections of the Skin," (British Journal of Dermatol, Dec., 1895, p. 378), narrated four cases of acute arsenical poisoning and four others from overdoses, giving the cutaneous eruptions of each, which collectively represented forms

of bright, rubioloid, erysipelatous or livid erythema; papules; painful vesicles (zoster cervico-subclavicularis once); blebs, split-pea to goose-egg sized; pustules and pea-sized boils; wart-like growths; œdema and thickening of the skin; fine desquamation, sometimes lamellar, especially marked on the palms and soles where the masses of epidermis were large and thick in three cases; hard (papular) points at the mouth of the sweat ducts; pigmentations and bronzings of the skin, once like nitrate of silver staining; crusts, ulcers and scars were also observed. Itching was a pronounced symptom in some cases and worse at night. He summarized his belief from a study of these cases as follows:

I. My cases are incontestible examples of skin disturbances produced by arsenic.

II. They prove that arsenical eruptions are not always similar in character.

III. That climate cannot imprint a dissimilarity on the form and degree of severity of the eruption.

IV. That race does not modify, except as to color, the aspect of the several arsenical outbreaks.

ANTITOXIN.-Dr. Moisard in a paper (Medical Press and Circular, Jan. 9th, 1895), said, in summarizing the observations of two hundred and thirty-one cases treated with antitoxin, that numerous instances of cutaneous manifestation were observed, sometimes attended with rheumatoid pains in the joints. "Among these, fourteen cases of urticaria, nine of scarlatiniform erythema, nine of polymorphic erythema, and one of purpura, were noted.

BORIC ACID.-A woman taking thirty grains a day of boric acid for cystitis, at the end of a month developed a multiform erythema of the trunk which extended to the upper extremities; at the same time there appeared a painful swelling of the upper lids with conjuctivitis and photophobia. The oedema became marked enough to close the eyes, and finally so intense as to similate the hardness of sclerosed tissue. Within a short time after suspending the boric acid, improvement set in and within a week both oedema and erythema had disappeared.— J. A. FORDYCE, in Journal Cuta. Gen-Urin. Dis., Dec., 1895.

COPAIBA.-J. Hutchinson, Jr., brought before the London Dermatological Society the case of a man aged 26, suffering with phymosis, some induration of the prepuce with considerable discharge from underneath, slight swelling of the inguinal glands, sore throat, and over nearly the whole cutaneous surface raised patches of bright red erythema, of which the earlier could be said to show the "lean-ham'' color of a syphilide. There was but little itching. The case could have been easily mistaken for syphilis. On inquiry it was found the man had been taking copaiba for three days previously without measuring the dose. Some members of the Society present, expressed their incredulity as to the rash being wholly due to copaiba. But subsequently on slitting up the prepuce no concealed chancres were found, only gonorrhoea and balanitis existed, and on simple treatment for the latter the eruption cleared off completely in a few days.—British Journal of Dermatology, June, 1895, p. 192.

EUROPHEN.-Dr. R. W. Taylor has reported (Journal Cuta. GenitoUrin. Dis., Dec., 1895, p. 505), a case of severe exudative erythema of the thigh and follicular erythema of the leg, from the local use of five grains of europhen on a sloughing gumma about the size of a silver quarter. The patient had previously used iodoform without any toxic effects. rophen contains about forty per cent. of iodoform.

CONDUCTED BY

H. WORTHINGTON Paige, M.D.

ALL NEWS or other matter relating to this department should be addressed to The Rutland, 256 West Fifty-seventh Street, New York City.

DR. R. P. FAY, of Yonkers, removed from 80 to 165 Warburton Avenue, on May 1st.

DR. J. W. DOWLING removed May 1st to 8 West Forty-fifth Street. Hours, 9:30 to 12; 7 to 7:30.

DR. LOUISE LANNIN has removed to 234 West Fifty-second Street. Hours, 10 to 1; 5 to 7.

DR. GEORGE W. McDoweLL has removed to 136 West 135th Street. Hours, 8 to 10 and 6 to 7.

THE PRACTITIONERS' CLUB devotes a part of each meeting to the study of Materia Medica.

THE METROPOLITAN BUILDING, No. 1 Madison Avenue, is to have a floor devoted to physicians' offices.

DR. EGBERT GUERNSEY removed, May 1st, to "The Madrid," 180 West Fifty-ninth Street.

AN INTERESTING ACCOUNT of the New England Hahnemann Association will be found in "Societies."

DRS. OLIN and LE SEURE will remove their offices on May 1st. to the Shurly Building, 32 Adams Ave., West.

DR. J. WILFORD ALLEN removed to 110 West Twelfth Street, on May 1st. Hours, 8 to 10, 5 to 7, and Sundays until 10.

Dr. F.

HELMUTH DREYER has changed his address to Webster Avenue, Fordham, New York City. Hours, 10 to 12 and 7 to 8. DR. JOHN B. PALMER has removed to the Ophthalmic Hospital, where he becomes House Surgeon. Hours, 8 to 12:30.

DR. LUCY M. SHEPHARD, recently associated with Dr. Sarah J. Millsop, Bowling Green, has located at Henderson, Kentucky.

DR. C. GURNEE FELLOWS, Chicago, business manager of the Clinique, visited his former home, New Orleans, during Mardi Gras.

DR. EDWIN S. MUNSON removed May 1st from Five Points Hospital to the Ophthalmic Hospital, in which he will be Assistant House

Surgeon.

Dr. F. G. RITCHIE retired from the House Surgeonship of the Ophthalmic Hospital, May 1st, and has located at 134 West Forty-seventh Street. Hours, 8:30 A. M. to I P. M.

THE SOUTHERN HOMEOPATHIC MEDICAL COLLEGE of Baltimore, Md., held its annual commencement exercises in Lehman's Hall, on Friday evening, April 10th, 1896.

IF THE MEMBERS OF THE INSTITUTE who ride bicycles take their wheels with them, they will find Detroit the most delightful place in the country for wheeling.

DR. HOWARD STOUT NEILSON has located at 257 East Forty-eighth Street, having concluded his service at the Flower Hospital. Hours, until 12 and 7 to 8 P.M.

DR. CSCAR N. MEYER, late Resident Physician at the Metropolitan Post-Graduate School of Medicine, has located at 118 East Ninetieth Street. Hours, until 11 and 6 to 7.

MICHIGAN'S representative homœopathic journal The Counselor will issue a daily edition during the sessions of the Institute devoting the entire profits of sales to the Monument fund.

THE MEMBERS of the Local Committee of Arrangements for the coming meetig of the Institute at Detroit are industriously working out the various plans of entertaining their visitors in June.

DR. HAROLD WILSON has been seriously afflicted with inflammatory rheumatism for the past month but under the excellent care of his father, Dr. T. P. Wilson, of Cleveland, he is on the mend.

Dr. Wilfred G. FRALICK, New York, has been appointed Surgeon to the Hahnemann Hospital and will devote himself, hereafter, exclusively to gynæcology and abdominal surgery.

་་

MEDICAL ETHICS'' was the title of an interesting and practical lecture delivered by Prof. F. E. Doughty, to the Hahnemann Society of the New York Homœopathic Medical College, on March 18th.

THE FORTY-SIX Annual MEETING of the Connecticut Homœopathic Medical Society will be held at Hartford, Tuesday, May 19, 1896, at Reports will be received from the Bureaux of Materia Medica, Clinical Medicine, Surgery, and Sanitary Science.

IO A. M.

DR. A. K. CRAWFORD, of Chicago, announces that he has removed his office to the Reliance Building, 100 State Street. Hours, II to I and 3 to 4. The Doctor sailed for a visit to Paris and London on the Fulda, via the Mediterranean, on April 25th.

THE NEW YORK HOMEOPATHIC MEDICal College AND HOSPITAL will hold its commencement on the afternoon of April 30th and the annual banquet of the Alumni Association will take place the same evening. In our next issue a full account will be given.

THE FINAL ARGUMENT before the Supreme Court of the Ann Arbor Removal bill was scheduled for April 7th, but on that date was postponed owing to the attorneys not being ready. It is assured, however, that the question will be settled in this present term of court.

WE PUBLISH THIS MONTH, in "Societies," a most excellent account of Homœopathy's Centennial by the Western New York Society in Buffalo on April 10th. The report was furnished by the courtesy of Dr. Wm. D. Young, to whom we express thanks for so good an account.

THE BOSTON HOMEOPATHIC HOSPITAL has received from the city a valuable gift of 12,000 feet of land for a Nurse's Home, and hopes to secure funds sufficient to erect a suitable building. We congratulate our brethren upon their success in securing such generous gifts for their hospital.

THE REGULAR EXAMINATION for Resident Physicians will be held on Friday, May 1st, 1896, at 12 o'clock, noon, at the Children's Homœopathic Hospital, 926 N. Broad Street, Philadelphia, Pa. Please send applications to Dr. J. M. Reeves, President of Medical Board, 1609 Mount Vernon Street.

THE NEW JERSEY STATE HOMOEOPATHIC MEDICAL SOCIETY expects to hold a large and interesting meeting in the State House, Trenton, on Tuesday, May 5th, beginning at 10:30 A. M. All physicians in this section are cordially invited to attend. It is hoped New York will be well represented.

THE HAHNEMANN CLUB, of Philadelphia, in consequence of the death of its member, Dr. M. M. Walker, decided not to hold any special celebration on April 10th. The main celebration of the homœopathic centennial in Philadelphia will be next September at which time the State society will be in session there.

DR. H. F. NICHOLS, of Hoboken, N. J., entertained the Machaon Club at dinner on the evening of the 1st, at the Hotel Washington, in Jersey City. The host presented an excellent paper on "Anomalous Scarlet Fever,'' which was ably discussed by those present, revealing the fact that typical cases were the exception and not the rule.

THE MAINE HOMEOPATHIC MEDICAL SOCIETY.-The thirtieth annual meeting will be held at Portland, Tuesday and Wednesday, June 2d and 3rd, 1896. All homoeopathic physicians in the State, not members, are invited to be present. Circulars of information will be sent them at their request. Cora M. Johnson, M.D., Skowhegan, Recording Secretary.

THE OMAHA HOMEOPATHIC PHYSICIANS gave an interesting and profitable course of medical lectures on March 16th, 17th, 18th, 19th and 20th, 1896. Each special branch received its evening and a series of most interesting papers was presented. The sessions were held in the office of Dr. O. S. Wood. The programme will be found in "Societies," this issue.

THE DISPENSARY QUESTION.--The following important resolution was adopted by the New York County Society at the regular meeting held April 9th, 1896:

Resolved: That in the opinion of this Society, all dispensaries should become incorporated institutions under the laws of the State of New York, within a year from the passage of this resolution.

THE ROENTGEN RAYS.-Dr. Wm. H. King gave an interesting lecture on the new radiance before a large audience in the Berkeley Lyceum Theatre, on Thursday evening, March 26th. Dr. F. M. Frazer made demonstrations of the new power, assisted by Messrs. Waite, Stollknecht, and Hewitt. The lecture was given under the auspices of the National Society of Electro-Therapeutists.

THEY SEEM A LITTLE CARELESS IN CHICAGO as to the disposition of dissecting material. The Century expresses astonishment that any comment at all should have been caused by the dumping of two mangled bodies in an alley in the residence portion of the city. We are not qualified to express any opinion in the premises as the plan and scope of the proceeding is a little different from that observed in the effete East.

ENTERTAINED at Dinner.-Dr. J. M. Lee, of Rochester, on March 6th entertained at dinner, at the Genesee Valley Club, Dr. Lewis Balch, health officer of the city of Albany and ex-secretary of the State Board of Health; Messrs. Goodwin Brown and Henry A. Reeves, of the State Commission on Lunacy; Dr. E. H. Wolcott, president of the State Homoopathic Medical Society, and Dr. E. H. Howard, superintendent of the Rochester State Hospital.