Metal Ions in Biological Systems: Volume 32: Interactions of Metal Ions with Nucleotides: Nucleic Acids, and Their ConstituentsAstrid Sigel, Helmut Sigel Volume 32 covers metal ion bonding to phosphate, sugar and nucleobase residues; the ambidentate as well as the stacking properties of nucleotides; kinetic aspects as well as properties of nucleobase and nucleotide analogs; and the oligonucleotides and nucleic acids. It examines electron transfer reactions over a large number of base repairs in DNA, the role of metal ions in ribozymes, ternary metal-nucleic acid base-protein complexes, metal responsive gene regulation, and the structure-activity relationships of anticancer drugs and their action on DNA, including cisplatin and the role of proteins. |
Contents
General Strategies in the Biodegradation of Pollutants | 1 |
Chapter | 2 |
MetalNucleotide Phosphate Interactions at Enzyme | 5 |
Mechanism of Action of Peroxidases | 7 |
Summary and Conclusions | 21 |
OF PURINES | 61 |
Chapter 5 | 76 |
Chapter 4 | 91 |
Chapter 11 | 397 |
Chapter 12 | 419 |
Structural Investigations of Metal Ion Complexes | 425 |
Analytical Method for Studying the Stability of Metal | 432 |
Role of Metal Ions in Carcinogenesis and Toxicity | 439 |
Conclusions | 447 |
Chapter 13 | 453 |
Conclusions | 472 |
3886 | 103 |
MetalMononucleotideAromatic Amine Ternary | 112 |
MetalOligonucleotide Complexes | 118 |
SOLUTION STRUCTURES OF NUCLEOTIDEMETAL | 135 |
Complexes of Nucleotide Analogs | 180 |
Summary and Outlook | 195 |
Osamu Yamauchi Akira Odani Hideki Masuda | 209 |
Intramolecular Stacking Interactions in Solution | 236 |
Concluding Remarks | 260 |
Hydrolysis of Nucleoside Phosphodiesters | 282 |
Hydrolysis of Phosphotriesters | 292 |
Chapter 8 | 301 |
Structure Types Protonation | 310 |
General Aspects of the Structures | 324 |
Conclusions | 331 |
Chapter 9 | 339 |
Steric and Electronic Tuning of Reactivity | 363 |
Conclusions | 369 |
Chapter 10 | 379 |
Conclusions | 390 |
Chapter 14 | 479 |
Chapter 15 | 521 |
Model Systems | 528 |
Metal IonPolynucleotidePolypeptide Complexes | 534 |
Conclusions and Outlook | 544 |
Chapter 16 | 557 |
Chapter 17 | 579 |
Chapter 18 | 603 |
Chapter 19 | 641 |
Outlook and Perspectives for Future Studies | 642 |
Structure of Platinum Compounds Bound to DNA | 652 |
Toxicity Resistance and Rescue Agents | 663 |
Chapter 20 | 687 |
The HMG Domain Family of Proteins | 703 |
Role of HMG Domain StructureSpecific Recognition | 709 |
NonHMG DomainContaining Proteins | 716 |
Chapter 21 | 727 |
| 781 | |
Common terms and phrases
¹H NMR 5'-monophosphate Acta adducts adenine adenosine amine amino antitumor activity atoms base binding at N7 binding sites Biochem Biochemistry Biol biological Ca2+ catalytic cations Cd2+ cell chelate Chem Chemistry Chim cis-DDP cisplatin Co² compounds coordination crosslinks crystal structure Cu2+ cytosine deprotonation dimer divalent electron enzymes formation guanine guanosine H₂O HMG domain hydrogen bonding hydrolysis imidazole Inorg inosine interstrand Ion Complexes isomer K₁ kinetic ligands log unit macrochelate metal binding metal bonding metal complexes metal ion binding metal-nucleotide Mg2+ Mn2+ moiety molecules N1 and N7 Ni² Ni2+ nitrogen nucleic acid nucleobases nucleophile nucleotides oligonucleotides oxygen Pd(II phosphate group platinated platinum plexes protein proton Pt(II purine R. B. Martin reaction residue ribose ribozyme S. J. Lippard Sigel species spectra stability constants stacking steric steric hindrance studies substitution sugar Table ternary tion trans trans-DDP uridine values zinc Zn(II Zn2+